abstract：OBJECTIVES:An intraoperative consultation (IOC) checklist was developed and implemented aimed at standardizing slide labeling and monitoring metrics central to quality and safety in surgical pathology. DESIGN:Data were collected for all IOC cases over a 9-month period. Slide labeling defect rates and IOC turnaround ti...

journal_title：American journal of clinical pathology

authors： Chen Y,Anderson KR,Xu J,Goldsmith JD,Heher YK

更新日期：2019-05-03 00:00:00

abstract：OBJECTIVES:To establish an objective, scientific, evidence-based process for planning statistical quality control (SQC) procedures based on quality required for a test, precision and bias observed for a measurement procedure, probabilities of error detection and false rejection for different control rules and numbers o...

journal_title：American journal of clinical pathology

authors： Westgard JO,Westgard SA

更新日期：2019-03-01 00:00:00

abstract：Objectives:Lymphoepithelioma-like carcinoma (LELC) of the uterine cervix is a rare tumor. The goal of this study was to evaluate a series of cases of cervical LELC and to investigate possible association with human papillomavirus (HPV) and/or Epstein-Barr virus (EBV). Methods:Immunohistochemistry for p63, p16, human l...

journal_title：American journal of clinical pathology

authors： Pinto A,Huang M,Nadji M

更新日期：2019-01-07 00:00:00

abstract：Objectives:To model renal function 2 years following radical nephrectomy with quantitative analyses using clinical, histopathologic, and renal composite cortical volumes (CCV). Methods:This retrospective study involved an assessment of the nonneoplastic kidney tissue by three blinded nephropathologists using modified ...

journal_title：American journal of clinical pathology

authors： Pruthi DK,Oomah S,Lu V,Ting T,Knickle C,Liss MA,Gibson IW,Kirkpatrick IDC,McGregor TB

更新日期：2019-01-01 00:00:00

abstract：Objectives:The aims were to evaluate breast cancer (BC) tumor-infiltrating lymphocytes (TILs) interobserver variability, heterogeneity, and the fidelity of scoring TILs in core needle biopsy (CNB). Methods:Matching CNB and two full-face sections (FFSs) of BC cases (n = 100) were independently reviewed by two pathologi...

journal_title：American journal of clinical pathology

authors： Khoury T,Peng X,Yan L,Wang D,Nagrale V

更新日期：2018-10-01 00:00:00

abstract：Objectives:The plasma-thrombin method is commonly used to make cell blocks from fine-needle aspiration (FNA) samples but requires centrifugation. We describe a modification to this method that does not require centrifugation for use in resource-limited settings. Methods:Pooled fresh plasma is aliquoted into 2-mL Eppen...

journal_title：American journal of clinical pathology

authors： Aisagbonhi O,Birungi A,Atwine R,Behayo P,Ayebaziwe B,Roberts D,Tambouret R

更新日期：2018-07-03 00:00:00

abstract：Objectives:To evaluate the prevalence of potentially unnecessary repeat testing (PURT) and the associated economic burden for an inpatient population at a large academic medical facility. Methods:We evaluated all inpatient test orders during 2016 for PURT by comparing the intertest times to published recommendations. ...

journal_title：American journal of clinical pathology

authors： Hueth KD,Jackson BR,Schmidt RL

更新日期：2018-05-31 00:00:00

abstract：Objectives:To evaluate the prognostic values of microRNAs (miRNAs) in glioblastoma, and to see if there is an association between miRNAs and MGMT promoter methylation status. Methods:We collected paraffin blocks from resection specimens from 114 glioblastoma patients who had received temozolomide treatment and radioth...

journal_title：American journal of clinical pathology

authors： Chen YY,Ho HL,Lin SC,Ho TD,Hsu CY

更新日期：2018-03-29 00:00:00

abstract：Objectives:To determine non-American Society for Clinical Pathology pathology- and laboratory-related Choosing Wisely recommendations that drive effective test utilization in the laboratory. Methods:Data were collected via a two-part web-based survey distributed to a broad sample of pathologists and laboratory profess...

journal_title：American journal of clinical pathology

authors： Waibel E,Garcia E,Kelly M,Soles R,Hilborne L

更新日期：2018-02-17 00:00:00

abstract：Objective:T-cell large granular lymphocytic (T-LGL) leukemia is associated with B-cell lymphomas (BCLs), especially small BCLs. We aimed to explore and expand upon its association with BCLs. Methods:We retrospectively studied clinicopathologic features of T-LGL leukemia patients with coexisting BCL from January 2001 t...

journal_title：American journal of clinical pathology

authors： Goyal T,Thakral B,Wang SA,Bueso-Ramos CE,Shi M,Jevremovic D,Morice WG,Zhang QY,George TI,Foucar KK,Bhattacharyya S,Bagg A,Rogers HJ,Bodo J,Durkin L,Hsi ED

更新日期：2018-01-29 00:00:00

abstract：Objectives:Early and accurate diagnosis remains crucial in the therapeutic management of invasive central nervous system fungal infections. Different molds have intrinsic resistance to antifungal agents; thus, morphologic differentiation is helpful to clinicians. Methods:Using three examples, we present a guide on how...

journal_title：American journal of clinical pathology

authors： Chavez JA,Brat DJ,Hunter SB,Velazquez Vega J,Guarner J

更新日期：2018-01-29 00:00:00

abstract：Objectives:Posttransplant lymphoproliferative disorders (PTLDs) are a heterogeneous group of hematolymphoid proliferations arising in the context of chronic immunosuppression. The common and indolent B-cell lymphomas, including extranodal marginal zone lymphomas (ENMZLs) of mucosa-associated lymphoid tissue (MALT), are...

journal_title：American journal of clinical pathology

authors： Cassidy DP,Vega F,Chapman JR

更新日期：2017-12-20 00:00:00

abstract：Objectives:To determine the impact of systemwide charge display on laboratory utilization. Methods:This was a randomized controlled trial with a baseline period and an intervention period. Tests were randomized to a control arm or an active arm. The maximum allowable Medicare reimbursement rate was displayed for tests...

journal_title：American journal of clinical pathology

authors： Schmidt RL,Colbert-Getz JM,Milne CK,Vargo DJ,Hussong JW,Hoidal JR,Markewitz BA,Walker BS,Kawamoto K

更新日期：2017-11-20 00:00:00

abstract：Objectives:Hemolyzed blood samples commonly occur in hospital emergency departments (EDs). Our objective was to determine whether replacing standard large-volume/high-vacuum sample tubes with low-volume/low-vacuum tubes would significantly affect ED hemolysis. Methods:This was a prospective intervention of the use of ...

journal_title：American journal of clinical pathology

authors： Phelan MP,Reineks EZ,Berriochoa JP,Schold JD,Hustey FM,Chamberlin J,Kovach A

更新日期：2017-10-01 00:00:00

abstract：Objectives:Fibromatosis of the breast is an uncommon neoplasm with potential for local recurrence. Treatment has traditionally been surgical excision with current trends toward conservative management. Given the option of observation after diagnosis by core needle biopsy (CNB), we sought to evaluate the accuracy of CNB...

journal_title：American journal of clinical pathology

authors： Kuba MG,Lester SC,Giess CS,Bertagnolli MM,Wieczorek TJ,Brock JE

更新日期：2017-09-01 00:00:00

abstract：Objectives:To curtail inappropriate plasma transfusions, we instituted clinical decision support as an alert upon order entry if the patient's recent international normalized ratio (INR) was 1.7 or less. Methods:The alert was suppressed for massive transfusion and within operative or apheresis settings. The plasma ord...

journal_title：American journal of clinical pathology

authors： Shah N,Baker SA,Spain D,Shieh L,Shepard J,Hadhazy E,Maggio P,Goodnough LT

更新日期：2017-08-01 00:00:00

abstract：Objectives:To analyze interobserver reproducibility and compare practice patterns between academic and community settings of Lower Anogenital Squamous Terminology (LAST). Methods:In total, 132 anal biopsy slides were revised as well as p16 immunostains. Results:LAST was used in 49% of cases (academic center, 68%; sat...

journal_title：American journal of clinical pathology

authors： Roma AA,Liu X,Patil DT,Xie H,Allende D

更新日期：2017-07-01 00:00:00

abstract：Objectives:To analyze the economic impact of testing for activated protein C resistance (APC-R) due to factor V Leiden (FVL) mutation with APC-R with reflexive FVL genotyping (algorithmic approach) or genotyping alone. Methods:OptumLabs Data Warehouse (OLDW) data were used to assess testing approaches. Insurance claim...

journal_title：American journal of clinical pathology

authors： Perez Botero J,Majerus JA,Strege AK,Johnson RD,Chen D,Pruthi RK

更新日期：2017-06-01 00:00:00

abstract：Objectives:To determine whether V H family usage in B-cell lymphoproliferative disorders can be deduced from polymerase chain reaction (PCR) product-length information obtained through the BIOMED-2 (Invivoscribe, San Diego, CA) clonality assay. Methods:We develop an algorithm that uses the sizing information of the BI...

journal_title：American journal of clinical pathology

authors： McDonald TJ,Kuo L,Kuo FC

更新日期：2017-06-01 00:00:00

abstract：Objectives:A report on the multicenter evaluation of the Bruker MALDI Biotyper CA System (MBT-CA; Bruker Daltonics, Billerica, MA) for the identification of clinically important bacteria and yeasts. Methods:In total, 4,399 isolates of medically important bacteria and yeasts were assessed in the MBT-CA. These included ...

journal_title：American journal of clinical pathology

authors： Wilson DA,Young S,Timm K,Novak-Weekley S,Marlowe EM,Madisen N,Lillie JL,Ledeboer NA,Smith R,Hyke J,Griego-Fullbright C,Jim P,Granato PA,Faron ML,Cumpio J,Buchan BW,Procop GW

更新日期：2017-06-01 00:00:00

abstract：Objectives:Free light chain (FLC) measurement gained a lot of interest for diagnostic workup of monoclonal gammopathy. Methods:We evaluated the performance of turbidimetric polyclonal Freelite (The Binding Site, Birmingham, UK) assays on Cobas 6000 (Roche Diagnostics, Rotkreuz, Switzerland) and nephelometric monoclona...

journal_title：American journal of clinical pathology

authors： Messiaen AS,De Sloovere MMW,Claus PE,Vercammen M,Van Hoovels L,Heylen O,Debrabandere J,Vanpoucke H,De Smet D

更新日期：2017-06-01 00:00:00

abstract：Objectives:Diagnosis of B-cell acute lymphoblastic leukemia (B-ALL) requires immunophenotypic evidence of B-lineage and absence of specific myeloid or T-lineage markers. Rare cases of otherwise typical B-ALL express myeloperoxidase (MPO) detectable by flow cytometry with an absence of other myeloid markers, but the cli...

journal_title：American journal of clinical pathology

authors： Oberley MJ,Li S,Orgel E,Phei Wee C,Hagiya A,O'Gorman MRG

更新日期：2017-04-01 00:00:00

abstract：Objectives:According to current guidelines, either immunohistochemistry (IHC) or in situ hybridization (ISH) can be used to determine human epidermal growth factor receptor 2 (Her2/neu) status in breast carcinoma. While the guidelines explicitly delineate result interpretation, there is no consensus on the most appropr...

journal_title：American journal of clinical pathology

authors： Solomon JP,Dell'Aquila M,Fadare O,Hasteh F

更新日期：2017-04-01 00:00:00

abstract：Objectives:To examine the relationship between the recently defined Gleason grade groups and prostate cancer-specific mortality. Methods:If the probability of prostate cancer-specific death is symbolized as P(PSD), the probability of biochemical failure is symbolized as P(BF), and the probability of prostate cancer-sp...

journal_title：American journal of clinical pathology

authors： Vollmer RT

更新日期：2017-03-01 00:00:00

abstract：Objectives:Approximately 15% of breast cancers show equivocal human epidermal growth factor receptor 2 (HER2) results on HER2 immunohistochemistry (IHC) and are reflexed for fluorescence in situ hybridization (FISH). However, some cases remain equivocal. In this study, we evaluated these double-equivocal cases by using...

journal_title：American journal of clinical pathology

authors： Hou Y,Nitta H,Li Z

更新日期：2017-01-01 00:00:00

abstract：OBJECTIVES:Mantle cell lymphoma (MCL) may present de novo or undergo progression to a clinically aggressive variant, known as a blastoid or pleomorphic variant. We report an unusual case of classic MCL in a 78-year-old man with a typical immunophenotype, including CD5 positivity, who subsequently relapsed with CD5-nega...

journal_title：American journal of clinical pathology

authors： Miao Y,Lin P,Wang W,Jeffrey Medeiros L,Lu X

更新日期：2016-12-01 00:00:00

abstract：OBJECTIVES:To examine Hedgehog signaling in cutaneous fibrosing disorders for which effective approved therapies are lacking, expand our knowledge of pathophysiology, and explore the rationale for targeted inhibition. METHODS:Stain intensity and percentage of cells staining for Sonic hedgehog (Shh), Indian hedgehog (I...

journal_title：American journal of clinical pathology

authors： Goyal A,Linskey KR,Kay J,Duncan LM,Nazarian RM

更新日期：2016-12-01 00:00:00

abstract：Objectives:Induction chemotherapy (IC) is occasionally used in head and neck cancer, leading to less extensive surgery and reduced need for irradiation. Factors predicting the response to IC have not been determined. In this study, we investigated the clinical and histopathologic factors that predict the response to IC...

journal_title：American journal of clinical pathology

authors： Karpathiou G,Giroult JB,Forest F,Fournel P,Monaya A,Froudarakis M,Dumollard JM,Prades JM,Gavid M,Peoc'h M

更新日期：2016-11-01 00:00:00

abstract：OBJECTIVES:Mutations in CALR (calreticulin) have been discovered in 50% to 80% of JAK2 (Janus kinase 2) and MPL (myeloproliferative leukemia protein) wild-type patients with Philadelphia-negative myeloproliferative neoplasm (MPNs). We evaluate the performance of a monoclonal antibody for immunohistochemical detection o...

journal_title：American journal of clinical pathology

authors： Nomani L,Bodo J,Zhao X,Durkin L,Loghavi S,Hsi ED

更新日期：2016-10-01 00:00:00

abstract：OBJECTIVES:The incidence of lymphoproliferative disorders (LPDs) is increasing in sub-Saharan Africa (SSA) due to population growth, aging, and human immunodeficiency virus (HIV). Despite significant burden, resources for diagnosis and treatment of LPDs are limited, with little infrastructure to deliver modern patholog...

journal_title：American journal of clinical pathology

authors： Montgomery ND,Liomba NG,Kampani C,Krysiak R,Stanley CC,Tomoka T,Kamiza S,Dhungel BM,Gopal S,Fedoriw Y

更新日期：2016-10-01 00:00:00

abstract：OBJECTIVES:Luminex-based single-antigen bead human leukocyte antigen (HLA) antibody testing is widely used to define HLA antibodies for transplant compatibility. False-negative results can occur with complement-mediated prozone inhibition. This study assessed the effect of EDTA on the assay background reactivity and fl...

journal_title：American journal of clinical pathology

authors： Anani WQ,Zeevi A,Lunz JG

更新日期：2016-09-01 00:00:00

abstract：OBJECTIVES:Timely reporting of immunosuppressant (ISP) drug level results is needed for transplant patient management. This study characterized the local ISP testing process, identified bottlenecks and implemented process improvements to meet turnaround time requirements. METHODS:Laboratory information time stamps, di...

journal_title：American journal of clinical pathology

authors： Barakauskas VE,Bradshaw TA,Smith LD,Lehman CM,Johnson-Davis KL

更新日期：2016-08-01 00:00:00

abstract：OBJECTIVES:To characterize error rates for genetic test orders between medical specialties and in different settings by examining detailed order information. METHODS:We performed a retrospective analysis of a detailed utilization management case database, comprising 2.5 years of data and almost 1,400 genetic test orde...

journal_title：American journal of clinical pathology

authors： Mathias PC,Conta JH,Konnick EQ,Sternen DL,Stasi SM,Cole BL,Astion ML,Dickerson JA

更新日期：2016-08-01 00:00:00

abstract：OBJECTIVES:We tried to describe cellular immune response (tertiary lymphoid structures (TLSs), lymphoid aggregates, tumor infiltrating lymphocytes (TILs)) in neoplastic microenvironment of ductal carcinoma in situ (DCIS) with or without associated microinvasion. METHODS:The histopathologic parameters of 177 DCIS and 2...

journal_title：American journal of clinical pathology

authors： Kim A,Heo SH,Kim YA,Gong G,Jin Lee H

更新日期：2016-07-01 00:00:00

abstract：OBJECTIVES:Blood specimen hemolysis is a major cause of sample recollection in the neonatal intensive care unit. We aimed to reduce the hemolysis rate from 6.3% at baseline to less than 4% within the 9 months' duration of the study. METHODS:Intravenous infusion of lipid emulsion during sample collection, sample collec...

journal_title：American journal of clinical pathology

authors： Tolan NV,Kaleta EJ,Fang JL,Colby CE,Carey WA,Karon BS,Baumann NA

更新日期：2016-07-01 00:00:00

abstract：OBJECTIVES:Tissue confirmation of the intrauterine location of a pregnancy can be difficult grossly, necessitating a frozen section diagnosis. First-trimester tissue is often scant and can be exhausted by frozen section. We examined 39 endometrial curettings performed for rule-out ectopic pregnancy by touch prep to exa...

journal_title：American journal of clinical pathology

authors： Chen AL,Tambouret RH,Roberts DJ

更新日期：2016-06-01 00:00:00

abstract：OBJECTIVES:We postulated that lymph node (LN) harvest and LN size are influenced by immunologic effects. METHODS:To investigate this hypothesis, we performed a retrospective analysis of 170 node-negative colon cancer cases to evaluate the density of intratumoral T lymphocytes (ITLs). CD3- and CD8-positive T cells were...

journal_title：American journal of clinical pathology

authors： Märkl B,Wieberneit J,Kretsinger H,Mayr P,Anthuber M,Arnholdt HM,Schenkirsch G

更新日期：2016-06-01 00:00:00

abstract：OBJECTIVES:We wished to discover (1) in what circumstances surgeons wished to request frozen sections (FSs) on thyroid nodules having a prior fine needle aspiration (FNA) and the preoperative plan in these cases; (2) what the surgeons did with the information provided by FS and (3) in what types of cases was value adde...

journal_title：American journal of clinical pathology

authors： Kennedy JM,Robinson RA

更新日期：2016-05-01 00:00:00

abstract：OBJECTIVES:Sentinel lymph node (SLN)-based diagnosis in gastric cancers has shown varied sensitivities and false-negative rates in several studies. Application of the reverse transcription-polymerase chain reaction (RT-PCR) in SLN diagnosis has recently been proposed. METHODS:A total of 155 SLNs from 65 patients with ...

journal_title：American journal of clinical pathology

authors： Kwak Y,Nam SK,Shin E,Ahn SH,Lee HE,Park do J,Kim WH,Kim HH,Lee HS

更新日期：2016-05-01 00:00:00

abstract：OBJECTIVES:Overuse of laboratory tests is a persistent issue. We examined the use and overuse of serum immunofixation electrophoresis and serum free light chain assays to develop an algorithm for optimizing utilization. METHODS:A retrospective review of all tests, for investigation of monoclonal gammopathies, for all ...

journal_title：American journal of clinical pathology

authors： Heaton C,Vyas SG,Singh G

更新日期：2016-04-01 00:00:00